Instrumentation
Proton-Transfer-Reaction Mass Spectrometry (PTR-MS)
Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) is a powerful real-time analytical technique used to detect and quantify ultra-trace volatile and semi-volatile organic compounds at parts-per-trillion levels. At RJ Lee Group, PTR-MS is deployed both in laboratory settings and through our mobile analytical laboratories, enabling rapid, on-site chemical characterization where time, sensitivity, and context matter most.
This mobility allows our experts to deliver immediate insight during contamination investigations, process evaluations, and emissions assessments—without the delays associated with off-site sample transport and analysis.
What is PTR-MS?
Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) is an advanced analytical technique used to detect and measure volatile and semi-volatile organic compounds in real time at parts-per-trillion (ppt) concentrations.
PTR-MS uses soft chemical ionization to selectively ionize compounds through proton transfer reactions, minimizing fragmentation and enabling accurate identification of trace chemicals without extensive sample preparation. When paired with time-of-flight (TOF) detection, PTR-MS delivers high mass resolution, rapid response times, and continuous chemical measurement.
These capabilities make PTR-MS especially valuable for environments where traditional laboratory methods are too slow, lack sensitivity, or are limited to predefined target analytes—such as advanced manufacturing, cleanroom operations, and emissions monitoring.
What Can You Do With PTR-MS?
RJ Lee Group applies PTR-MS and PTR-TOF-MS to solve complex chemical challenges where speed, sensitivity, and chemical insight are critical.
Key Applications Include:
- Ultra-Trace Chemical Detection
Detect and quantify VOCs and SVOCs at ppt levels, including trace contaminants that may impact yield, reliability, or compliance. - Contamination & Root Cause Investigations
Rapidly identify airborne, process-related, or material-derived contaminants to support root cause analysis and corrective action. - Process & Emissions Monitoring
Monitor manufacturing environments, tool exhaust, and process streams in real time to identify chemical releases, trends, and anomalies. - PFAS & Emerging Contaminant Screening
Detect volatile PFAS precursors, fluorinated compounds, and next-generation process chemistries that may not appear in traditional target lists. - Alternative Chemistry & Substitution Studies
Evaluate replacement materials or process changes with immediate feedback on unintended chemical impacts. - Product Stewardship & Regulatory Support
Generate defensible data to support TSCA, TRI, state PFAS reporting, customer disclosures, and ESG initiatives.
PTR-MS enables faster decision-making by delivering actionable chemical insight in minutes—rather than days or weeks.
Why Choose RJ Lee Group for PTR-MS Analysis?
RJ Lee Group offers PTR-MS as part of an integrated analytical and consulting service, not as a standalone instrument output. Our value lies in combining advanced technology with deep scientific, regulatory, and industry expertise.
With RJ Lee Group, you benefit from:
- Expert Interpretation, Not Just Data
Our scientists translate complex mass spectral data into clear, defensible conclusions that support operational and regulatory decisions. - Semiconductor & Advanced Manufacturing Experience
We understand the materials, processes, and risk tolerance of semiconductor and microelectronics environments. - Integrated Analytical Capabilities
PTR-MS results are supported by complementary techniques—thermal analysis, microscopy, spectroscopy, and materials characterization—when deeper insight is needed. - Rapid, Real-World Problem Solving
PTR-MS is deployed strategically to address high-impact challenges—contamination events, process changes, emerging chemical risks—when timing matters most.
Get in Touch
In an era of accelerating chemical restrictions and shrinking tolerances, real-time chemical intelligence is a competitive advantage. RJ Lee Group helps you apply PTR-MS to protect innovation, ensure compliance, and maintain operational resilience.
Contact us today to learn how our expert PTR-MS services, including our mobile testing laboratories, can provide you with the data you need to remain safe, compliant, and competitive.
Blog
Read More
10 min read
Unlocking the Secrets of Materials: The Power of X-ray Diffraction (XRD) and X-ray Fluorescence (XRF)
October 01, 2024